Aging and Life-Prolonging Processes by Prof. Dr. Vladimir Veniaminovich Frolkis (auth.)

By Prof. Dr. Vladimir Veniaminovich Frolkis (auth.)

There is an Inca incantation which said stated approximately: "Lord, supply me religious peace in order that i will be able to acquiesce to what i can't switch, provide me braveness in order that i will switch what i will swap, and provides me knowledge in order that i will distinguish one from the opposite. " evidently, this incantation may be on a regular basis repeated by way of any gerontologist, because it is especially tricky to differentiate getting older from the techniques which complement the organism's viability, getting older from ailments, and the mechanisms of getting older in numerous species of animals. in line with N. surprise, who compiled a priceless bibliography of the works on getting older, greater than 43,000 works on gerontology were released within the final decade. Why can we proceed to disagree with each other and carry that an important mechanisms are nonetheless mostly unknown to us regardless of that movement of knowledge and an immense variety of proof? what's it that we don't be aware of? might or not it's that we don't understand the only real sacramental truth which may clarify every little thing, corresponding to the hormone of getting older, the programmed triggering of a suicide gene, the looks of a different poisonous agent within the axoplasmic circulate of gear, and so on? Goethe as soon as wrote scientist in general holds convinced elements, yet regrettably he lacks their sacred link.

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E. the area of the nuclear membranes increases and individual organoids become hypertrophied (Fig. 11 A, B). According to the adaptive regulatory theory of aging, important adaptive shifts occur together with atrophy and destructive changes as the organism grows old. This principle has been confirmed by an analysis of the structural changes in the brain. Those manifestations are expressed to a different extent in various parts of the brain. They include the hypertrophy of many neurons, the appearance of polyploid nerve cells, the growth of the surface of the cell and its nucleus, an increase in the number of nucleoli, the intensified coloration of nuclear chromatin that is not connected with pyknosis, an increase in the volume of mitochondria as their number decreases, the growth of dendrodendritic and axosomal contacts in some structures, a change in the spina apparatus, the hypertrophy of micro tubules as a part of them is destroyed, etc.

1972) Frontal polar region (area 10) -28 human 19-28 vs. 77 years M,F Shefer, V. F. (1972) Middle temporal gyrus (area 21) -23 human 19-28 vs. 77 years M,F Shefer, V. F. (1972) Structural and Metabolic Changes in the Brain During Aging 37 Table 1 (continued) Brain structures Changes Species Age Sex Reference % Cerebral cortex (frontal pole, area striata, cingulate gyrus, precentral gyrus) Visual co rtex (area 17) Indusium griseum Colon, E. J. human to 90 years -24 Fischer 344 rat 11 vs. 29 months M Ordy, J.

The neurophysiological mechanisms of parkinsonism are connected with a disturbance in the motor regulation centres, the striapallidal system, and Substantia nigra. In this respect, the metabolism of catecholamines is disturbed and the dopamine content is sharply reduced. Definite shifts in this system occur in many elderly persons, i. e. the electric activity of the muscles is higher at rest, light tremor is frequent, and so forth. Clearly expressed parkinsonism develops when the brain vessels are greatly affected by atherosclerosis against that background in some of these persons.

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