Advances in Nanotheranostics I: Design and Fabrication of by Zhifei Dai

By Zhifei Dai

This e-book highlights the hot advances in nanotheranostics from uncomplicated learn to power functions, and discusses the modular layout and engineering of multiplex nanoparticles together with gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. every one bankruptcy demonstrates multifunctional nanoparticles with themes overlaying focusing on, imaging, supply, diagnostics, and treatment as new modalities for melanoma theranostics. This finished booklet provides professional perspectives at the most modern advancements in theranostic nanomedicine.

It makes a speciality of power theranostic purposes of multifunctional nanoparticles starting from opting for noninvasively melanoma cells via molecular detection, and visualizing in vivo drug supply through distinction more desirable imaging, to destroying melanoma telephone s with minimum negative effects through selective accumulation at tumor websites, and real-time tracking healing effectiveness. It additionally offers an interdisciplinary survey of nanotheranostics and as such is a important source for researchers and scholars in similar fields.

Zhifei Dai is a Professor on the division of Biomedical Engineering, university of Engineering, Peking college, China.

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Combined treatments with p65 siRNA photothermal transfection and chemotherapeutic agent irinotecan caused substantially enhanced tumor apoptosis and growth delay compared to other treatment regimens, which indicated photothermal transfection of NF-κB p65 siRNA could enhance sensitivity to chemotherapeutic agents. Lu et al. also reported theranostic HAuNSs with multifunctions including tumor targeting, PAT imaging, and photothermal therapy [129]. By targeting brain tumor receptors via RGD peptides, the theranostic HAuNSs exhibited highly specific tumor diagnosis.

Oyelere AK, Chen PC, Huang XH, El-Sayed IH, El-Sayed MA (2007) Peptide-conjugated gold nanorods for nuclear targeting. Bioconjug Chem 18:1490–1497 46. Ding H, Yong KT, Roy I et al (2007) Gold nanorods coated with multilayer polyelectrolyte as contrast agents for multimodal imaging. J Phys Chem C 111:12552–12557 47. Kang B, Mackey MA, El-Sayed MA (2010) Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. J Am Chem Soc 132:1517–1519 48.

The modulation in molecular levels helps us understand the underlying major mechanism of the cellular effects and predicts the potential risk of nanomaterials for biomedical applications. In the end, most animal models were highly specific; thus the replicative results of biological effects and biomedical applications are sometimes hard to achieve. Predicting and evaluating toxicity of the designed Au nanostructures in vitro should base on systematic studies about how the varied factors regulate cellular effects, by combining conventional techniques for molecular and cell biology, multi-omicsbased techniques, and some novel techniques in nanotoxicology.

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