Acute Leukemias: Prognostic Factors and Treatment Strategies by P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof.

By P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Priv.-Doz. Dr. W. Hiddemann, Prof. Dr. D. Urbanitz, Prof. Dr. J. Ritter (eds.)

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The possibility that some autocrine growth factors are secreted and utilized has also been considered, but not investigated extensively. However, recent studies with recombinant granulocyte/macrophage colonystimulating factor (GM-CSF) have suggested that L-CFC proliferation in a large proportion of ANLL patients can be effectively induced by that factor [6]. Moreover, in some patients, it was possible to demonstrate the constitutive secretion of a growth factor with GM-CSF biological activity by leukemic cells.

Numerical chromosome changes (without morphologic abnormalities) Specific (Primary) Karyotypic Change It is now generally accepted that the primary (specific) chromosome change in acute leukemia is probably related to, ifnot necessary for, the process of malignant transformation and closely associated with those molecular events which may, in fact, be responsible for this transformation, if not for the causation 1 Department of Genetics and Endocrinology Roswell Park Memorial Institute, Buffalo, NY 14263, USA.

Blood 66:1448 13 7. Herrmann F, Oster W, Lindemann A, Ganser A, Dorken B, Knapp W, Griffin JD, Mertelsmann R (1986) Leukemic-colony-forming in acute myeloblastic leukemia: maturation, hierarchy, and growth conditions. In: Neth R, Gallo RC (eds) Modem trends in leukemia, Vol 7. Springer, Berlin Heidelberg New York Tokyo (to be published) 8. Herrmann F, Cannistra SA, Griffin JD (1986) T cell-monocyte interactions in the production of humoral factors regulating human granulopoieses in vitro. J Immunol136:2856 9.

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