By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Within the Bhopal catastrophe of 1984, nearly 2,000 citizens dwelling close to a chemical plant have been killed and 20,000 extra suffered irreversible harm to their eyes and lungs following the unintended free up of methyl isocyanate. This tragedy served to concentration foreign realization at the desire for governments to spot dangerous elements and support neighborhood groups in making plans tips to care for emergency exposures. on account that 1986, the U.S. Environmental security supplier has been tasked with picking super damaging components and, in cooperation with the Federal Emergency administration supplier and the dept of Transportation, support neighborhood emergency reaction planners. The nationwide Advisory Committee on Acute publicity guide degrees for unsafe components was once verified in 1995 to strengthen acute publicity instruction degrees (AEGLs) for top precedence poisonous chemical substances that may be published into the air from injuries at chemical vegetation, garage websites, or in the course of transportation. This publication experiences toxicity files on 5 chemical substances - chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride - for his or her clinical validity, comprehensives, inner consistency, and conformance to the 1993 directions record.
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Additional resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Vol 1
0 mg of aniline/kg of body weight) to two human subjects resulted in an increase in methemoglobin content to 11% (Brodie and Axelrod 1948). 6% in methemoglobin within 1 to 4 h. 1% in an adult male volunteer (Jenkins et al. 1972). The maximum level in the volunteer was reached 2 h after administration and returned to normal 1 h later. 2 mg/kg). ) of 5, 15, and 25 mg on successive mornings followed by treatment of some of these volunteers with 35, 45, 55, and 65 mg, whereas the rats, which were fed ad libitum, were administered a single treatment by gastric intubation.
2% in rabbits. 1 mg/g of hemoglobin. Jenkins et al. 9%. For two other methemoglobinforming chemicals, acetanilide and acetophenetidine, humans were half as susceptible as the cat and one-tenth as susceptible as the rat (Calabrese 1991). 6%), and dogs had an increase of chromogen in their urine, although circulating methemoglobin was not elevated. No clear species differences could be distinguished among these minor effects. 5 h following administration (Khan et al. 1997). 0 mg of aniline/kg of body weight) to two human subjects resulted in an increase in methemoglobin content to 11% (Brodie and Axelrod 1948).
3. 1. Acute Lethality Acute lethality data are summarized in Table 1–4 and discussed below. About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files. Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution.